Epstein-Barr virus in monitoring the response to therapy of acquired immunodeficiency syndrome-related primary central nervous system lymphoma

1999 ◽  
Vol 45 (2) ◽  
pp. 259-261 ◽  
Author(s):  
Andrea Antinori ◽  
Antonella Cingolani ◽  
Andrea De Luca ◽  
Gianluca Gaidano ◽  
Adriana Ammassari ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acquired Immunodeficiency Syndrome ◽  
Epstein Barr Virus ◽  
Central Nervous System Lymphoma ◽  
Response To Therapy ◽  
Barr Virus ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Central nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome

2000 ◽  
Vol 92 (4) ◽  
pp. 688-692 ◽  
Author(s):  
Ann M. Ritter ◽  
Barbara H. Amaker ◽  
R. Scott Graham ◽  
William C. Broaddus ◽  
John D. Ward
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acquired Immunodeficiency Syndrome ◽  
Content Type ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Histological Characteristics ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

✓ Leiomyosarcomas (LMSs) of the central nervous system are extremely rare; however, they are becoming more prevalent in immunocompromised patients. The authors present the cases of two patients with acquired immunodeficiency syndrome: one with LMS of the thoracic vertebral body and the other with LMS originating from the region of the cavernous sinus. The epidemiological and histological characteristics of LMS and its association with latent Epstein—Barr virus are discussed, as well as the treatments for this neoplasm.

Epstein-Barr virus in AIDS-related primary central nervous system lymphoma

The Lancet ◽  
1991 ◽  
Vol 338 (8773) ◽  
pp. 969-973 ◽  
Author(s):  
E. MacMahon ◽  
P. Charache ◽  
D. Glass ◽  
R.B. Mann ◽  
P.S. Becker ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Epstein Barr Virus ◽  
Central Nervous System Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma [see comments]

Blood ◽  
1991 ◽  
Vol 77 (5) ◽  
pp. 1092-1095 ◽  
Author(s):  
A Neri ◽  
F Barriga ◽  
G Inghirami ◽  
DM Knowles ◽  
J Neequaye ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Epstein Barr Virus ◽  
Clonal Expansion ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Non Hodgkin Lymphoma ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Abstract The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome- associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is a passenger virus has not been conclusively demonstrated. One element to distinguish between these two possibilities is to determine whether EBV infection has preceded and, thus, possibly contributed to clonal expansion, or whether infection has occurred after clonal expansion and thus is unlikely to contribute to pathogenesis. Toward this end we analyzed the structure of the heterogeneous genomic termini of EBV as markers of clonal infection in a panel of eBL (11 cases), sBL (9 cases), and AIDS-NHL (10 cases) biopsies. We show that EBV termini are uniformly clonal in sBL, eBL, and AIDS-NHL, strongly suggesting that EBV infection has preceded and, thus, most likely contributed to clonal expansion in these malignancies.

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